Spindle cell sarcoma with a fgfr1 fusion

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August undefined, 2024

WebDec 1, 2024 · Histologically, this was a spindle cell neoplasm with coagulative necrosis, moderate cytologic atypia, and increased mitotic activity. By immunohistochemistry, the neoplastic cells coexpressed CD34 and S100, and lacked smooth muscle marker expression. RNA sequencing revealed the presence of a FGFR1-TACC1 gene fusion. WebNov 6, 2024 · It is notable that the fusion involves NCOA2 as the 3′ fusion partner as seen in spindle cell ... Pascasio JM, Punnett HH, Halligan GE, de Chadarévian JP (2011) FOXO1-FGFR1 fusion and amplification in a solid variant of alveolar rhabdomyosarcoma. ... Schuller U, Jones DTW, von Deimling A (2024) Primary intracranial spindle cell sarcoma with ...

Clinical Impact of Prospective Whole Genome Sequencing in Sarcoma …

WebNov 2, 2024 · First Description of a Giant Spindle-Cell Myxoid Tumor with an FGFR1-CAPRIN1 Fusion on the Back of an Infant’s Hand. R. Staubach* , H. Glosse, E. Koscielniak, C. Vokuhl, O. Diez, S. Loff. Annals of Case Reports. research article. Pdf Html 2024-10-30. WebNational Center for Biotechnology Information ma livebox free

Sarcomas with spindle cell morphology - PubMed

WebFeb 14, 2024 · Abstract. Purpose: Altered FGFR1 signaling has emerged as a therapeutic target in epithelial malignancies. In contrast, the role of FGFR1 in soft-tissue sarcoma (STS) has not been established. Prompted by the detection and subsequent therapeutic inhibition of amplified FGFR1 in a patient with metastatic leiomyosarcoma, we investigated the … WebSpindle cell sarcomas (malignant fibrous histiocytoma, hemangiopericytoma, fibrosarcoma, leiomyosarcoma, synovial sarcoma) are the most common primary pulmonary sarcomas.256–259 On radiologic images, they are more commonly located in the periphery of the lung, although central and endobronchial masses are reported. 257,258,260–262 … WebJan 21, 2024 · We report an aggressive soft tissue sarcoma with FGFR1-TACC1 fusion occurring in the thigh of an 83-year-old man. Microscopically, the tumour was composed of monomorphic spindle cells arranged in intersecting fascicles. The tumour cells showed ovoid nuclei, fine chromatin, indistinct nucleoli and elongated eosinophilic cytoplasm. malive speak up 2035mood0001b

Spindle Cell Sarcoma - an overview ScienceDirect Topics

The novel finding of an FGFR1::TACC1 fusion in an undifferentiate…

WebOct 13, 2024 · Immunohistochemically, there was a clear positivity for CD34 and FGFR1-CAPRIN1 fusion which was detected by RNA panel sequencing. The fusion described … WebJan 21, 2024 · The finding of FGFR1‐TACC1 fusion in a high‐grade, undifferentiated spindle cell sarcoma of soft tissue is novel and may offer a potential therapeutic target in the near future. This article ... malivelihood weddingWebThe new categorization of uterine spindle cell sarcomas in 2009 started a new era of pathological diagnosis depending on molecular features from classical morphology. With only five cases previously reported, we presented the sixth case of COL1A1–PDGFB fusion uterine sarcoma in the female genital tract. Its pathological morphology is easily ... maliver urology indiana pa

"WebJan 21, 2024 · The fusion junction of the chimeric transcript involved FGFR1 exon 16 and TACC1 exon 7, which was similar to those reported in other types of neoplasms such as … " - Spindle cell sarcoma with a fgfr1 fusion

Spindle cell sarcoma with a fgfr1 fusion

WebThe novel finding of an FGFR1::TACC1 fusion in an undifferentiated spindle cell sarcoma of soft tissue with aggressive clinical course. Yau DT, Lacambra MD, Chow C, To KF Genes … WebWith the growing availability of RNA sequencing technology in the pathology laboratory, new gene fusion-associated malignancies are increasingly being characterized.In this article, we describe the second ever reported case of a uterine sarcoma harboring a FGFR1-TACC1 gene fusion.The patient, a 53-yr-old perimenopausal woman, was found to have a 6 cm …

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WebNov 1, 2024 · Histologically, this was a spindle cell neoplasm with coagulative necrosis, moderate cytologic atypia, and increased mitotic activity. By immunohistochemistry, the … WebSpindle cell sarcomas (malignant fibrous histiocytoma, hemangiopericytoma, fibrosarcoma, leiomyosarcoma, synovial sarcoma) are the most common primary pulmonary …

WebDec 1, 2024 · NTRK fusion-positive uterine spindle cell sarcomas constitute a novel tumor type with features of fibrosarcoma; patients with these tumors may benefit from Trk … WebFeb 11, 2024 · Strong cytoplasmic pan-TRK immunostaining was observed in a mediastinal solitary fibrous tumor with confirmed NAB2-STAT6 fusion (A, B), a spindle cell rhabdomyosarcoma harboring MYOD1 p.L122R ...

Webpatients with FGFR1 amplification or FGFR fusion may benefit from FGFR targeted therapy which needs further clinical investigation. Keywords: FGFR1 amplification, FGFR fusion, … WebSoft-tissue sarcomas are rare, comprising <1% of all cancer diagnoses. Yet the diversity of histological subtypes is impressive with >100 benign and malignant soft-tissue tumor entities defined. Not infrequently, these neoplasms exhibit overlapping clinicopathologic features posing significant challenges in rendering a definitive diagnosis and optimal …

WebJan 21, 2024 · The finding of FGFR1‐TACC1 fusion in a high‐grade, undifferentiated spindle cell sarcoma of soft tissue is novel and may offer a potential therapeutic target in the near …

WebSep 9, 2024 · The tumor was resected with an initial diagnosis elsewhere of probable benign spindle cell tumor. The tumor locally recurred in 2 years and was excised again. The … m a living limitedWeb1 day ago · Download Citation On Apr 14, 2024, Koshi Akahane and others published FGFR1 tyrosine kinase domain duplication in infantile soft tissue spindle cell tumor Find, read and cite all the research ... mali vs south africa results malivore powersWebGenes 2014, 5 446 The JAK2 V617F mutation is detectable in approximately 95% of all PV patients and 50% of both ET and PMF patients [7–9]. It is further detected in patients with refractory anemia with ring sideroblasts and thrombocytosis (RARS-T), but in less than 5% of patients with acute myeloid maliwan blacksite locationWebFeb 12, 2024 · Neurotrophic tyrosine receptor kinase (NTRK)-rearranged spindle cell neoplasm is a recently described soft tissue tumor entity that occurs predominantly in … malivore from legaciesWebMar 1, 2015 · Interestingly, unlike the prototypical leukaemia‐inducing FGFR1 fusion genes, the FN1–FGFR1 chimeric protein was predicted to preserve its ligand‐binding domains, … mali vs rwanda predictionWebFor three patients, previously diagnosed with an alveolar rhabdomyosarcoma, embryonal rhabdomyosarcoma and undifferentiated pleiomorphic sarcoma (UPS) of the jaw, respectively, their diagnosis was revised to spindle cell/sclerosing rhabdomyosarcoma based on a MYOD1 p.Leu122Arg mutation in two patients, and an FUS–TFCP2 fusion in … maliwah dogs pictures