WebNov 14, 2008 · Successive paliperidone ER administrations will be separated by a washout period of at least 14 days and no more than 28 days. Paroxetine is a potent and selective CYP2D6 inhibitor. Inhibitors of CYP2D6 such as paroxetine have been reported to increase the plasma concentrations of antipsychotics such as perphenazine, clozapine, and … WebDec 17, 2024 · Paliperidone is also not a substrate of CYP1A2, CYP2A6, CYP2C9, and CYP2C19; an interaction with inhibitors or inducers of these isozymes is unlikely. …
Metabolism of atypical antipsychotics: involvement of …
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Absorption, Metabolism, and Excretion of Paliperidone, a New ...
WebApr 1, 2010 · Paliperidone is an atypical antipsychotic drug [1, 2].It is identical to 9-hydroxyrisperidone, the pharmacologically active metabolite of risperidone, and has a similar pharmacological profile as risperidone, exhibiting high affinities for the dopamine D 2 and the serotonin 5-HT 2 receptor [3, 4].Paliperidone has been made commercially available as … WebGenotype and co-medication dependent CYP2D6 metabolic activity: effects on serum concentrations of aripiprazole, haloperidol, risperidone, paliperidone and zuclopenthixol … Web26 rows · Tab: tablet; ODT: orally dissolving tablet; LAI: long-acting injectable (eg, depot); CYP: cytochrome P-450; UGT-glucuronidation: uridine 5'diphosphate … bank of india uttam nagar pune