Webb16 mars 2024 · In particular, there is significant interest in the role of inhaled polymyxins for the treatment of nosocomial pneumonia, including ventilator-associated pneumonia, due to their retained activity against multi-drug resistant Gram-negative pathogens, including Acinetobacter baumannii and Pseudomonas aeruginosa. Webb24 maj 2024 · Inhaled polymyxins are of considerable utility in achieving optimal exposure in the respiratory tract for the treatment of lung infections caused by multidrug-resistant Gram-negative pathogens. Current inhaled polymyxin therapy is empirical, and often large doses are used that may lead to potential pulmonary adverse effects.
A Breath of Fresh Air in the Fog of Antimicrobial Resistance: Inhaled ...
Webb1 juli 2016 · The polymyxin B and colistin are recommended for serious systemic infections caused by gram-negative bacteria that are resistant to other agents and have a role in the therapy of multidrug-resistant gram- negative bacterial infections. 526 Highly Influential View 6 excerpts, references methods WebbFor inhaled polymyxins, no studies to date have utilized Monte Carlo simulations to calculate potential PTAs to recommend dosage regimens. Table 2. Suggested loading and daily doses of colistimethate for a target colistin C ss,avg of 2 mg/L in various categories of critically-ill patients. parole office fort gratiot mi
Polymyxin-Induced Metabolic Perturbations in Human Lung
Webb1 juni 2007 · The use of inhaled polymyxin B was started after failure with intravenous in most of our cases of nosocomial pneumonia caused by resistant Gram-negative bacilli, … Webb24 feb. 2024 · Inhaled polymyxins are increasingly used to treat pulmonary infections caused by multidrug-resistant Gram-negative pathogens. We have previously shown that apoptotic pathways, autophagy and oxidative stress are involved in polymyxin-induced toxicity in human lung epithelial cells. In the present study, we employed human lung … Webb17 aug. 2024 · Inhaled polymyxins are used for the treatment of lung infections caused by MDR Gram-negative pathogens, particularly in people with cystic fibrosis (20, 21). However, to date, there remains a dearth of mechanistic understanding of polymyxin-induced lung toxicity. parole office hanford ca