WebThe gray platelet syndrome (GPS) is a rare inherited disorder characterized by mild to moderate bleeding tendency, moderate thrombocytopenia, and a marked decrease or absence of platelet alpha-granules and of the proteins contained in alpha-granules. WebGray platelet syndrome (GPS) is a mild to moderate bleeding diathesis characterized by the presence of macrothrombocytopenia and gray-appearing platelets on the peripheral blood smear.180 Electron microscopy demonstrates the presence of alpha granules that are virtually empty ( Figs. 10-5 and 10-6 ).

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WebJan 10, 2013 · Electron microscopy subsequently showed absence of α-granules. The name GPS comes from the gray appearance of the platelets in the peripheral blood smear as … WebFeb 15, 2024 · Gray platelet syndrome (GPS) is a rare platelet storage pool disorder associated with a marked decrease or absence of platelet α-granules and their contents. It is characterized clinically by mild to moderate bleeding; moderate macrothrombocytopenia with large, agranular platelets; splenomegaly; and bone marrow fibrosis. flag with black bird and red

Gray platelet syndrome - Rare Disease Day 2024

WebThe gray platelet syndrome (GPS) is a rare inherited disorder of the megakaryocyte (MK) lineage. Thrombocytopenia and enlarged platelets are associated with a specific absence of alpha-granules and their contents. GPS patients exhibit much heterogeneity both in bleeding severity and in their response to platelet function testing. WebThe gray platelet syndrome (GPS) (OMIM #139090) is a rare autosomal recessive disorder characterized by moderate macrothrombocytopenia, marked decrease or absence of … WebThe gray platelet syndrome (GPS) is a rare inherited disorder characterized by mild to moderate bleeding tendency, moderate thrombocytopenia, and a marked decrease or absence of platelet alpha-granules and of the proteins contained in alpha-granules. canon printer toolbox download windows 10