Glut9 isoform2
WebAug 13, 2024 · Uric acid (UA) is a metabolite of purine degradation and is involved in gout flairs and kidney stones formation. GLUT9 (SLC2A9) was previously shown to be a urate transporter in vitro. In vivo, humans carrying GLUT9 loss-of-function mutations have familial renal hypouricemia type 2, a condition characterized by hypouricemia, UA renal wasting … WebClinVar archives and aggregates information about relationships among variation and human health.
Glut9 isoform2
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WebGlucose transporter 9 (GLUT9), which transports urate in an electrogenic and voltage-dependent manner, plays an important role in the maintenance of normal blood uric acid/urate levels. In the present study, we established a cell model based on the single-electrode patch-clamp technique for characte … WebResults showed that at least three GLUT isoforms (GLUT1, GLUT3 and GLUT9) are expressed by normal chondrocytes. Given the central role of glucose in chondrocyte physiology and metabolism, its regular provision via GLUTs will influence the metabolic activity and survival of chondrocytes in cartilage matrices.
WebNational Center for Biotechnology Information WebSep 8, 2009 · Recent genetic studies revealed a strong link between urate plasma levels and single nucleotide polymorphisms in the SLC2A9 gene encoding Glut9, a member of …
WebJun 18, 2024 · SLC2A9 or Glut9 is a voltage sensitive urate transporter, mainly expressed in the kidneys, the liver, and the intestine. Human Glut9 loss-of-function mutations were identified in familial hypouricemia, and … WebKNOWAtlanta features 16 Metro Atlanta counties like Fulton, Cobb, Decatur and Gwinnett to help you choose the best area to live. Simply click on the county or city name to find …
WebThe full-length cDNA of PcLGBP isoform2 was 1440 bp containing an ORF of 1245 bp encoding a protein of 414 amino acids. Predicted PcLGBP isoform1 and PcLGBP …
WebJul 1, 2024 · (A), Before treatment with SGLT2 inhibitors. (B), After treatment with SGLT2 inhibitors. The urate reabsorption pathway involves apical exchanger proteins URAT1, … ottu movie imdbWebAug 25, 2024 · Glut9-flox mice were constructed and hybrid with Alb-Cre mice to breed Glut9 liver-specific knockout (Glut9 Hep−ko) mice, and the Glut9-flox (Glut9 Fl/Fl) mice were used as control. The hepatic Glut9 knockdown effect was confirmed by detection of mRNA level of Glut9 in mouse liver samples (Supplementary Figure S2). イクラ 格安WebSep 8, 2009 · We show that Glut9 is expressed in the basolateral membrane of hepatocytes and in both apical and basolateral membranes of the distal nephron. Mice with systemic knockout of Glut9 display moderate hyperuricemia, massive hyperuricosuria, and an early-onset nephropathy, characterized by obstructive lithiasis, tubulointerstitial inflammation, … ottumwa aspen dentalWebOct 22, 2024 · Hyperuricemia plays a critical causative role in gout. In contrast, hyperuricemia has a protective effect in neurodegenerative disorders, including Alzheimer’s Disease. Genetic variation in the … いくら寿司 英語WebDownload scientific diagram The N-terminal domain of human GLUT9 isoforms play a significant role in functional activation of by insulin. (A,B) The [ 14 C]-urate uptake … いくら寿司WebAug 10, 2015 · The tumour suppressor Merlin, encoded by the gene NF2, is frequently mutated in the autosomal dominant disorder neurofibromatosis type II, characterised primarily by the development of schwannoma and other glial cell tumours. However, NF2 is expressed in virtually all analysed human and rodent organs, and its deletion in mice … ottumwa cab servicesWebDec 20, 2024 · SGLT2阻害薬はSGLT2を阻害することによって尿中にブドウ糖を排泄するため、管腔内の高濃度ブドウ糖が近位尿細管管腔側への尿酸の排泄を促進し、集合管 … ottumwa camera