Dethiobiotin synthetase

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August undefined, 2024

WebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this … WebMar 9, 2024 · Dethiobiotin synthetase catalyzes the first ring closure in the biosynthesis of biotin, which is the penultimate step in the biosynthesis pathway. [More information is available at EcoCyc: EG10120]. Other designations dethiobiotin synthetase GeneRIFs: Gene References Into Functions N-terminus verified by Edman degradation on mature …

Dethiobiotin Synthetase: The Carbonylation of 7,8 …

WebOct 15, 1998 · The crystal structure of the 224-residue protein dethiobiotin synthetase from Escherichia coli has been refined using X-ray diffraction data at 0.97 A resolution at 100 K. The model, consisting of 4143 protein atoms including 1859 H atoms and 436 solvent sites, was refined to a final R factor of 11 ... Macromolecules WebJan 1, 1979 · This chapter presents an overview of dethiobiotin (DTB) synthetase. The interrelationship between 7,8-diaminopelargonic acid and DTB has been first established when both vitamers have been found to satisfy the biotin requirement of … how to send email with php

Structural Characterization of the Mycobacterium tuberculosis …

WebThis article is cited by 32 publications. Andrew P. Thompson, Wanisa Salaemae, Jordan L. Pederick, Andrew D. Abell, Grant W. Booker, John B. Bruning, Kate L. Wegener, Steven W. Polyak. Mycobacterium tuberculosis Dethiobiotin Synthetase Facilitates Nucleoside Triphosphate Promiscuity through Alternate Binding Modes. WebThe levels of dethiobiotin synthetase in Escherichia co2i have been increased 6-fold over the wild type when pre- pared from a X-lysogen carrying the bioD gene under phage control. The purification procedure employed gave a nearly … WebMar 31, 1998 · The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The … how to send emails directly to a folder

RCSB PDB - 1A82: DETHIOBIOTIN SYNTHETASE FROM …

Structural characterization of Helicobacter pylori dethiobiotin ...

WebSpecifically, DTBS allows for the ATP-dependent formation of dethiobiotin from 7,8-diaminopelargonic acid (DAPA) and CO 2 by catalyzing a ureido ring formation(4). The … WebSep 5, 1995 · Crystal structure of two quaternary complexes of dethiobiotin synthetase, enzyme-MgADP-AlF 3 -diaminopelargonic acid and enzyme-MgADP-dethiobiotin … how to send email with recipients hiddenWebApr 30, 2012 · The Two-Step Synthesis of DTB from KAPA. (A) In bacteria, DTB is synthesized from KAPA by two distinct enzymes encoded by bioA and bioD genes, respectively, catalyzing successively DAPA-AT and DTBS reactions. AdoMTOB, S -adenosyl-2-oxo-4-methylthiobutyric acid. how to send emails in your outbox

"WebMar 31, 1998 · The ATP-dependent enzyme dethiobiotin synthetase from Escherichia coli catalyses the formation of dethiobiotin from CO2 and 7, 8-diaminopelargonic acid. The reaction is initiated by the formation of a carbamate and proceeds through a phosphorylated intermediate, a mixed carbamic phosphoric anhydride ... Macromolecules " - Dethiobiotin synthetase

Dethiobiotin synthetase

Dethiobiotin: Uses, Interactions, Mechanism of Action - DrugBank

WebApr 16, 2010 · Dethiobiotin synthetase (DTBS) is involved in the biosynthesis of biotin in bacteria, fungi, and plants. As humans lack this pathway, DTBS is a promising antimicrobial drug target. We determined structures of DTBS from Helicobacter pylori (hpDTBS) bound with cofactors and a substrate analog, and described its unique characteristics relative to ... WebAug 31, 1998 · The crystal structures of two complexes of dethiobiotin synthetase, enzyme-diaminopelargonic acid-MgADP-AlF3 and enzyme-dethiobiotin-MgADP-Pi, respectively, have been determined to 1.8 A …

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In enzymology, a dethiobiotin synthase (EC 6.3.3.3) is an enzyme that catalyzes the chemical reaction ATP + 7,8-diaminononanoate + CO2 ADP + phosphate + dethiobiotin The 3 substrates of this enzyme are ATP, 7,8-diaminononanoate, and CO2, whereas its 3 products are ADP, phosphate, and dethiobiotin. WebGSE12663: virulence determinants of Francisella tularensis revealed by transcriptional profiling inside macrophages: GSE42863: Flagellar export apparatus protein, FliH, is involved in post-transcriptional regulation of FlaB, motility and virulence of the relapsing fever spirochete Borrelia hermsii

WebMay 1, 1994 · Background In Escherichia coli, the enzymes of the biotin biosynthesis pathway are encoded by the bio operon. One of these enzymes, ATP-dependent dethiobiotin synthetase, catalyzes the carboxylation of 7,8-diaminopelargonic acid leading to the formation of the ureido ring of biotin. The enzyme belongs to the class of ATP … WebApr 7, 2024 · Atlanta, city, capital (1868) of Georgia, U.S., and seat (1853) of Fulton county (but also partly in DeKalb county). It lies in the foothills of the Blue Ridge Mountains in …

Biotin synthase (BioB) (EC 2.8.1.6) is an enzyme that catalyzes the conversion of dethiobiotin (DTB) to biotin; this is the final step in the biotin biosynthetic pathway. Biotin, also known as vitamin B7, is a cofactor used in carboxylation, decarboxylation, and transcarboxylation reactions in many organisms including humans. Biotin synthase is an S-Adenosylmethionine (SAM) dependent enzym… WebApr 17, 2024 · The ureido ring of dethiobiotin is formed by the enzyme dethiobiotin synthase (DTBS). The final step involves the insertion of sulfur and is catalyzed by the enzyme biotin synthase (BS).

WebMay 8, 1995 · The crystal structures of six complexes of homodimeric Escherichia coli dethiobiotin synthetase with a variety of substrates, substrate analogs, and products …

WebPubMed how to send email with time scheduleWebSep 5, 1995 · Dethiobiotin synthetase (DTBS) catalyzes the penultimate step in biotin biosynthesis, the formation of the ureido ring of dethiobiotin from (7R,8S)-7,8-diaminononanoic acid (7,8-diaminopelargonic acid, DAPA), CO2, and ATP. Solutions of DAPA at neutral pH readily formed a mixture of the N7- and N8-carbamates in the … how to send emails from your outboxWebDethiobiotin synthetase (DTBS; E.C. 6.6.6.6), the penultimate enzyme in the biosynthesis of the essential vitamin biotin, is a new potential target for novel herbicides. Inhibitors … how to send emails on pcWebMay 8, 1995 · These include (1) the binary complex of dethiobiotin synthetase and the N7-carbamate of 7,8-diaminononanoic acid, (2) the binary complex of enzyme and the alternate substrate, 3-(1-aminoethyl)-nonanedioic acid, (3) the binary complex of enzyme with the product ADP, (4) the quaternary complex of enzyme, ADP, the N7-carbamate of 7,8 ... how to send emails separatelyWebProtein target information for Bifunctional dethiobiotin synthetase/7,8-diamino-pelargonic acid aminotransferase, mitochondrial (thale cress). Find diseases associated with this biological target and compounds tested against it in bioassay experiments. how to send emails in quickbooksWebNov 1, 2000 · Sequence analysis of this fragment revealed that it is closely related to a family of ATP-dependent enzymes that also includes dethiobiotin synthetase and the synthetase domains of two amidotransferases involved in cobalamin biosynthesis, cobyrinic acid a,c-diamide synthase (CobB) and cobyric acid synthase (CobQ). how to send emails to folder outlookWebJan 1, 1979 · This chapter presents an overview of dethiobiotin (DTB) synthetase. The interrelationship between 7,8-diaminopelargonic acid and DTB has been first established … how to send emails to focused inbox